Cardiac patients uninformed about dangerous food and drug interactions
MONTREAL, Oct. 25 /CNW Telbec/ - Cardiac medications mixed with certain foods and herbal supplements can endanger patients' health, especially in those taking multiple medications.
A paper by Nancy Chaytor presented today at the Canadian Cardiovascular Congress 2005, co-hosted by the Heart and Stroke Foundation of Canada and the Canadian Cardiovascular Society, says there is a knowledge deficit in this area. Her presentation described many known food-drug interactions which clinicians should, but don't always, discuss with patients.
"It is vital that people taking cardiac medications are aware of these potentially dangerous interactions, and that they tell their doctor everything they are taking" says Dr. Beth Abramson, Heart and Stoke Foundation spokesperson. "Through my own research on complementary and alternative medicines I know that sharing that information is critical, but often doesn't
happen."
"The way the body metabolizes medications and foods can result in a drug being either less effective or too potent - and this can have life or death consequences," says Chaytor, a nurse practitioner in medical cardiology with the Calgary Health Region who prescribes medications. A drug's potency can be affected by many factors including genetics, age, gender, disease states, diet, or social factors. A single glass of grapefruit juice can increase or,less commonly, decrease the level of a drug in your blood.
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Some potentially dangerous interactions include
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Medication Food/herbal product
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Medications for high blood pressure Grapefruit and grapefruit juice
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Medications for irregular heart Grapefruit and grapefruit juice
rhythms
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Monoamine Oxidase (MAO) Foods high in tyramine (such
inhibitors as beer, wine, certain cheeses,
and sausages)
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Warfarin (an anticoagulant) Grapefruit and grapefruit juice
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Warfarin Food with vitamin K (such as
liver, broccoli, Brussel sprouts,
green leafy vegetables)
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Warfarin Ginkgo biloba
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Warfarin Ginseng
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Anticoagulants (blood thinners) Papaya extract
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Anticoagulants (blood thinners) Devil's claw
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Anticoagulants (blood thinners) Smoking cigarettes
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For example, smokers on anticoagulant medications may not think to tell their physician they are cutting down or quitting. But smoking makes these medications less effective, so physicians prescribe smokers an increased dosage. If a patient quits, the dose will be too high - potentially putting the patient's health at risk.
Herbal preparations, like such as garlic supplements, may seem harmless but they may interact with blood pressure or anticoagulant medications. That is why it is important to always tell your doctor or healthcare provider about all supplements you are taking.
Chaytor looked at the CYP450 system - a group of proteins found mostly in the part of the liver where metabolism takes place. These proteins can be directly affected by the consumption of certain foods and herbal remedies and can either increase or decrease the effectiveness of a drug.
"It's important that clinicians are well-informed about these interactions and educate their patients," says Chaytor.
The Heart and Stroke Foundation ( www.heartandstroke.ca ) is a leading funder of heart and stroke research in Canada. The Foundation's mission is to improve the health of Canadians by preventing and reducing disability and death from heart disease and stroke through research, health promotion and advocacy.